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TargetHistone acetyltransferase KAT2A/KAT2B
LigandBDBM311486
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1654184
IC50 19±n/a nM
Citation Humphreys PGBamborough PChung CWCraggs PDGordon LGrandi PHayhow TGHussain JJones KLLindon MMichon AMRenaux JFSuckling CJTough DFPrinjha RK Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem 60:695-709 (2017) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Histone acetyltransferase KAT2A/KAT2B
Name:Histone acetyltransferase KAT2A/KAT2B
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:93045.76
Organism:Homo sapiens (Human)
Description:ChEMBL_1502838
Residue:832
Sequence:
MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
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  Blast E-value cutoff:
BDBM311486
n/a
NameBDBM311486
Synonyms:CHEM-US-00192 | US10155764, Example 65B
TypeSmall organic molecule
Emp. Form.C19H23N5O
Mol. Mass.337.4188
SMILESC[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccccc1 |r|
Structure
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