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TargetProteasome subunit beta type-5
LigandBDBM50234962
Substrate/Competitorn/a
Meas. Tech.ChEBML_1654306
IC50 1.000000±n/a nM
Citation Zhuang, RGao, LLv, XXi, JSheng, LZhao, YHe, RHu, XShao, YPan, XLiu, SHuang, WZhou, YLi, JZhang, J Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors. Eur J Med Chem126:1056-1070 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteasome subunit beta type-5
Name:Proteasome subunit beta type-5
Synonyms:20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:Protein
Mol. Mass.:28480.96
Organism:Homo sapiens (Human)
Description:n/a
Residue:263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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  Blast E-value cutoff:
BDBM50234962
n/a
NameBDBM50234962
Synonyms:CHEMBL4078056
TypeSmall organic molecule
Emp. Form.C37H48ClN7O5S
Mol. Mass.738.339
SMILESCC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)NCc1nccs1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r|
Structure
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