Reaction Details |
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Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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Ligand | BDBM50235021 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1654407 (CHEMBL4003773) |
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IC50 | >1000±n/a nM |
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Citation | Shi, Y; Park, J; Lagisetti, C; Zhou, W; Sambucetti, LC; Webb, TR A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett27:406-412 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
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Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D3 |
Synonyms: | CDK4/Cyclin D3 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1806445 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33731.96 |
Organism: | Homo sapiens (Human) |
Description: | P11802 |
Residue: | 303 |
Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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Component 2 |
Name: | G1/S-specific cyclin-D3 |
Synonyms: | CCND3 | CCND3_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 32521.90 |
Organism: | Homo sapiens (Human) |
Description: | P30281 |
Residue: | 292 |
Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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BDBM50235021 |
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n/a |
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Name | BDBM50235021 |
Synonyms: | CHEMBL4104657 |
Type | Small organic molecule |
Emp. Form. | C20H27ClN8 |
Mol. Mass. | 414.935 |
SMILES | CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12 |r| |
Structure |
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