| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
|---|
| Ligand | BDBM50235022 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1654402 (CHEMBL4003768) |
|---|
| IC50 | 17±n/a nM |
|---|
| Citation |  Shi, Y; Park, J; Lagisetti, C; Zhou, W; Sambucetti, LC; Webb, TR A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett27:406-412 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK1 |
|---|
| Name: | Dual specificity protein kinase CLK1 |
|---|
| Synonyms: | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57322.21 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49759 |
|---|
| Residue: | 484 |
|---|
| Sequence: | MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESR
SINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH
HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECID
HKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV
FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSD
YTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC
DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWD
EHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL
KKSI
|
|
|
|---|
| BDBM50235022 |
|---|
| n/a |
|---|
| Name | BDBM50235022 |
|---|
| Synonyms: | CHEMBL4078898 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H27ClN8 |
|---|
| Mol. Mass. | 414.935 |
|---|
| SMILES | CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
