Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM50391781 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1654945 (CHEMBL4004311) |
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IC50 | 49±n/a nM |
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Citation | Chobanian, HR; Guo, Y; Pio, B; Tang, H; Teumelsan, N; Clements, M; Frie, J; Ferguson, R; Guo, Z; Thomas-Fowlkes, BS; Felix, JP; Liu, J; Kohler, M; Priest, B; Hampton, C; Pai, LY; Corona, A; Metzger, J; Tong, V; Joshi, EM; Xu, L; Owens, K; Maloney, K; Sullivan, K; Pasternak, A The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics. Bioorg Med Chem Lett27:1109-1114 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44809.08 |
Organism: | Homo sapiens (Human) |
Description: | gi_223460826 |
Residue: | 391 |
Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM50391781 |
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n/a |
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Name | BDBM50391781 |
Synonyms: | CHEMBL2146873 | US9073882, 38 |
Type | Small organic molecule |
Emp. Form. | C23H24FN3O2 |
Mol. Mass. | 393.454 |
SMILES | Fc1cc(CCN2CCN(CCc3ccc4C(=O)OCc4c3)CC2)ccc1C#N |
Structure |
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