| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily D member 3 |
|---|
| Ligand | BDBM50235240 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1655140 (CHEMBL4004506) |
|---|
| IC50 | 2300±n/a nM |
|---|
| Citation |  Wolkenberg, SE; Nolt, MB; Bilodeau, MT; Trotter, BW; Manley, PJ; Kett, NR; Nanda, KK; Wu, Z; Cato, MJ; Kane, SA; Kiss, L; Spencer, RH; Wang, J; Lynch, JJ; Regan, CP; Stump, GL; Li, B; White, R; Yeh, S; Dinsmore, CJ; Lindsley, CW; Hartman, GD Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett27:1062-1069 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium voltage-gated channel subfamily D member 3 |
|---|
| Name: | Potassium voltage-gated channel subfamily D member 3 |
|---|
| Synonyms: | KCND3 | KCND3_HUMAN | Kv channel-interacting protein 2/Potassium voltage-gated channel subfamily D member 3 | Potassium voltage-gated channel subfamily D member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv4.3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 73464.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1478652 |
|---|
| Residue: | 655 |
|---|
| Sequence: | MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLER
YPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAF
YGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTST
LALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE
YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKF
SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWY
TIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR
AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLL
HCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHP
GLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDG
LRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSIASNVVKVSAL
|
|
|
|---|
| BDBM50235240 |
|---|
| n/a |
|---|
| Name | BDBM50235240 |
|---|
| Synonyms: | CHEMBL4065169 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21FN4O2S |
|---|
| Mol. Mass. | 448.513 |
|---|
| SMILES | CS(=O)(=O)Nc1cccc(n1)[C@@H](C(c1cccnc1)c1cccnc1)c1ccc(F)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
