| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C eta type |
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| Ligand | BDBM33971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1655173 (CHEMBL4004539) |
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| IC50 | 6.1±n/a nM |
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| Citation |  van Eis, MJ; Evenou, J; Schuler, W; Zenke, G; Vangrevelinghe, E; Wagner, J; von Matt, P Indolyl-naphthyl-maleimides as potent and selective inhibitors of protein kinase C-a/ß. Bioorg Med Chem Lett27:781-786 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C eta type |
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| Name: | Protein kinase C eta type |
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| Synonyms: | KPCL_HUMAN | PKC-L | PKCL | PRKCH | PRKCL | Protein Kinase C, eta | Protein kinase C, PKC; classical/novel | nPKC-eta |
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| Type: | Enzyme |
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| Mol. Mass.: | 77844.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 683 |
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| Sequence: | MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTK
QKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEG
WVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQRAMRRRVHQINGHKFMATYLR
QPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRF
GINIPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAV
ELAKTLAGMGLQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVNSSNRLGIDNFEFIRV
LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF
CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDL
KLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAM
GVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL
TQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDE
GHLPMINQDEFRNFSYVSPELQP
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| BDBM33971 |
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| n/a |
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| Name | BDBM33971 |
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| Synonyms: | AEB071 | Sotrastaurin | med.21724, Compound 190 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6O2 |
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| Mol. Mass. | 438.4812 |
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| SMILES | CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1 |t:11| |
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| Structure | 
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