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TargetDihydrofolate reductase
LigandBDBM22985
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1657484 (CHEMBL4006954)
IC50 31.3±n/a nM
Citation Patel, TSVanparia, SFPatel, UHDixit, RBChudasama, CJPatel, BDDixit, BC Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition. Eur J Med Chem129:251-265 (2017) [PubMed]  Article
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:Enzyme
Mol. Mass.:21603.71
Organism:Bos taurus (Cattle)
Description:P00376
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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BDBM22985
n/a
NameBDBM22985
Synonyms:Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
TypeAntimalarial
Emp. Form.C18H26ClN3
Mol. Mass.319.872
SMILESCCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure
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