Reaction Details |
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Target | Polycomb protein EED |
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Ligand | BDBM223986 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1657640 (CHEMBL4007110) |
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IC50 | 660±n/a nM |
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Citation | Curtin, ML; Pliushchev, MA; Li, HQ; Torrent, M; Dietrich, JD; Jakob, CG; Zhu, H; Zhao, H; Wang, Y; Ji, Z; Clark, RF; Sarris, KA; Selvaraju, S; Shaw, B; Algire, MA; He, Y; Richardson, PL; Sweis, RF; Sun, C; Chiang, GG; Michaelides, MR SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg Med Chem Lett27:1576-1583 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polycomb protein EED |
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Name: | Polycomb protein EED |
Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
Type: | Protein |
Mol. Mass.: | 50201.68 |
Organism: | Homo sapiens (Human) |
Description: | O75530 |
Residue: | 441 |
Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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BDBM223986 |
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n/a |
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Name | BDBM223986 |
Synonyms: | (3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine (3) |
Type | Small organic molecule |
Emp. Form. | C24H28FN3 |
Mol. Mass. | 377.4976 |
SMILES | CN(C)[C@H]1CN(C[C@@H]1c1cn(C)c2ccccc12)[C@H]1CCc2cccc(F)c12 |r| |
Structure |
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