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TargetPolycomb protein EED (EED)
LigandBDBM50235648
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1657638
Ki 2.6±n/a nM
Citation Curtin MLPliushchev MALi HQTorrent MDietrich JDJakob CGZhu HZhao HWang YJi ZClark RFSarris KASelvaraju SShaw BAlgire MAHe YRichardson PLSweis RFSun CChiang GGMichaelides MR SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg Med Chem Lett 27:1576-1583 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polycomb protein EED (EED)
Name:EZH2/SUZ12/EED/RBBP7/RBBP4
Synonyms:EED | Polycomb protein EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:Protein
Mol. Mass.:50201.68
Organism:Homo sapiens (Human)
Description:O75530
Residue:441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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  Blast E-value cutoff:
BDBM50235648
n/a
NameBDBM50235648
Synonyms:CHEMBL4081496
TypeSmall organic molecule
Emp. Form.C26H35FN4O
Mol. Mass.438.5807
SMILESCN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)C(C)=O |r|
Structure
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