| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-hexosaminidase subunit alpha |
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| Ligand | BDBM50235813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657985 (CHEMBL4007597) |
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| IC50 | 100±n/a nM |
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| Citation |  Front, S; Biela-Banas, A; Burda, P; Ballhausen, D; Higaki, K; Caciotti, A; Morrone, A; Charollais-Thoenig, J; Gallienne, E; Demotz, S; Martin, OR (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomalß-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. Eur J Med Chem126:160-170 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-hexosaminidase subunit alpha |
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| Name: | Beta-hexosaminidase subunit alpha |
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| Synonyms: | Beta-N-acetylhexosaminidase subunit alpha | Beta-hexosaminidase subunit alpha (HexA) | HEXA | HEXA_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 60688.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06865 |
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| Residue: | 529 |
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| Sequence: | MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
YLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
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| BDBM50235813 |
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| n/a |
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| Name | BDBM50235813 |
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| Synonyms: | CHEMBL4097052 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H30N2O5 |
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| Mol. Mass. | 366.4519 |
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| SMILES | CC(=O)N[C@H]1[C@@H](COCCCCc2ccccc2)N[C@H](CO)[C@@H](O)[C@@H]1O |r| |
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| Structure | 
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