| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase D3 |
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| Ligand | BDBM50235820 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658128 (CHEMBL4007740) |
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| IC50 | >10000±n/a nM |
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| Citation |  Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg Med Chem Lett26:5562-5567 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase D3 |
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| Name: | Serine/threonine-protein kinase D3 |
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| Synonyms: | EPK2 | KPCD3_HUMAN | PRKCN | PRKD3 | Protein kinase C nu | Protein kinase C nu type | Protein kinase C, PKC | Protein kinase C, PKC; classical/novel | Protein kinase EPK2 | Serine/threonine-protein kinase D3 (PKD3) | classical/novel | nPKC-nu |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 100475.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_5031689 |
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| Residue: | 890 |
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| Sequence: | MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV
SFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSEN
ILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVR
QGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEES
HVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGM
QCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDT
EEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKE
GWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQG
SNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASV
CTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGR
DVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDML
EMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCD
FGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDE
DINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLD
LREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
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| BDBM50235820 |
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| n/a |
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| Name | BDBM50235820 |
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| Synonyms: | CHEMBL4066664 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11F3N6O |
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| Mol. Mass. | 348.2826 |
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| SMILES | FC(F)(F)CNc1nc(Nc2ccc3cn[nH]c3c2)nc2ccoc12 |
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| Structure | 
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