| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 |
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| Ligand | BDBM50235817 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658117 (CHEMBL4007729) |
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| IC50 | >10000±n/a nM |
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| Citation |  Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg Med Chem Lett26:5562-5567 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek2 |
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| Name: | Serine/threonine-protein kinase Nek2 |
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| Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51776.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51955 |
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| Residue: | 445 |
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| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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| BDBM50235817 |
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| n/a |
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| Name | BDBM50235817 |
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| Synonyms: | CHEMBL4078893 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17ClF3N5O2 |
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| Mol. Mass. | 427.808 |
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| SMILES | FC(F)(F)CNc1nc(Nc2ccc(N3CCOCC3)c(Cl)c2)nc2ccoc12 |
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| Structure | 
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