| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
|---|
| Ligand | BDBM50235816 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1658079 (CHEMBL4007691) |
|---|
| IC50 | 1910±n/a nM |
|---|
| Citation |  Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg Med Chem Lett26:5562-5567 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcium/calmodulin-dependent protein kinase kinase 2 |
|---|
| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
|---|
| Synonyms: | CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 64746.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_27437015 |
|---|
| Residue: | 588 |
|---|
| Sequence: | MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
|
|
|
|---|
| BDBM50235816 |
|---|
| n/a |
|---|
| Name | BDBM50235816 |
|---|
| Synonyms: | CHEMBL4069365 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18F3N5O3 |
|---|
| Mol. Mass. | 421.3731 |
|---|
| SMILES | CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
