| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
|---|
| Ligand | BDBM50235830 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1658078 (CHEMBL4007690) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Hoemann, M; Wilson, N; Argiriadi, M; Banach, D; Burchat, A; Calderwood, D; Clapham, B; Cox, P; Duignan, DB; Konopacki, D; Somal, G; Vasudevan, A Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg Med Chem Lett26:5562-5567 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha |
|---|
| Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
|---|
| Synonyms: | CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54093.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_25952118 |
|---|
| Residue: | 478 |
|---|
| Sequence: | MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLERE
ARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQIL
EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL
SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV
TPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLK
GAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEA
ISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIH
LMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
|
|
|
|---|
| BDBM50235830 |
|---|
| n/a |
|---|
| Name | BDBM50235830 |
|---|
| Synonyms: | CHEMBL2006765 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19F3N6O |
|---|
| Mol. Mass. | 392.3783 |
|---|
| SMILES | CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
