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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM24663
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1658250
IC50 1200±n/a nM
Citation Tomek PPalmer BDFlanagan JUSun CRaven ELChing LM Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. Eur J Med Chem 126:983-996 (2017) [PubMed]  Article
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Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM24663
n/a
NameBDBM24663
Synonyms:2-(1H-imidazol-4-yl)phenol | 2-(1H-imidazol-4-yl)phenol, 1
TypeSmall organic molecule
Emp. Form.C9H8N2O
Mol. Mass.160.1726
SMILESOc1ccccc1-c1c[nH]cn1
Structure
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