| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50140172 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658487 (CHEMBL4008099) |
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| IC50 | 66±n/a nM |
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| Citation |  Nelson, KM; Dahlin, JL; Bisson, J; Graham, J; Pauli, GF; Walters, MA The Essential Medicinal Chemistry of Curcumin. J Med Chem60:1620-1637 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3, beta | GSK3B_RAT | Glycogen Synthase Kinase-3, beta | Gsk3b |
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| Type: | Enzyme |
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| Mol. Mass.: | 46754.43 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | The rat GSK-3 beta cDNA was inserted into the baculovirus vector. The protein was purified from virus-infected sf9 insect cells |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDM
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
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| BDBM50140172 |
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| n/a |
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| Name | BDBM50140172 |
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| Synonyms: | CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Table 1, Compound 21: curcumin |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20O6 |
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| Mol. Mass. | 368.3799 |
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| SMILES | COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O |
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| Structure | 
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