| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polycomb protein EED |
|---|
| Ligand | BDBM50235989 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1658555 |
|---|
| IC50 | 62±n/a nM |
|---|
| Citation |  Huang, Y; Zhang, J; Yu, Z; Zhang, H; Wang, Y; Lingel, A; Qi, W; Gu, J; Zhao, K; Shultz, MD; Wang, L; Fu, X; Sun, Y; Zhang, Q; Jiang, X; Zhang, J; Zhang, C; Li, L; Zeng, J; Feng, L; Zhang, C; Liu, Y; Zhang, M; Zhang, L; Zhao, M; Gao, Z; Liu, X; Fang, D; Guo, H; Mi, Y; Gabriel, T; Dillon, MP; Atadja, P; Oyang, C Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem60:2215-2226 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polycomb protein EED |
|---|
| Name: | Polycomb protein EED |
|---|
| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50201.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75530 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
|
|
|
|---|
| BDBM50235989 |
|---|
| n/a |
|---|
| Name | BDBM50235989 |
|---|
| Synonyms: | CHEMBL4067448 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13N5O |
|---|
| Mol. Mass. | 315.3287 |
|---|
| SMILES | N#Cc1cc(-c2ccccc2)c2nncn2c1NCc1ccco1 |
|---|
| Structure | 
|
|---|
Search and Browse
