| Reaction Details |
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 | Report a problem with these data |
| Target | EZH2/SUZ12/EED/RBBP7/RBBP4 |
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| Ligand | BDBM172038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658555 |
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| IC50 | 40±n/a nM |
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| Citation |  Huang Y; Zhang J; Yu Z; Zhang H; Wang Y; Lingel A; Qi W; Gu J; Zhao K; Shultz MD; Wang L; Fu X; Sun Y; Zhang Q; Jiang X; Zhang J; Zhang C; Li L; Zeng J; Feng L; Zhang C; Liu Y; Zhang M; Zhang L; Zhao M; Gao Z; Liu X; Fang D; Guo H; Mi Y; Gabriel T; Dillon MP; Atadja P; Oyang C Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem 60:2215-2226 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| EZH2/SUZ12/EED/RBBP7/RBBP4 |
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| Name: | EZH2/SUZ12/EED/RBBP7/RBBP4 |
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| Synonyms: | EED | Polycomb protein EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
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| Type: | Protein |
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| Mol. Mass.: | 50201.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75530 |
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| Residue: | 441 |
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| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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| BDBM172038 |
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| n/a |
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| Name | BDBM172038 |
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| Synonyms: | US10155002, Compound 44 | US9090562, 143 | US9090562, 44 | US9394283, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H44N4O4 |
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| Mol. Mass. | 572.7376 |
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| SMILES | CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1 |
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| Structure | 
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