| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-directed RNA polymerase, mitochondrial |
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| Ligand | BDBM50236025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658646 (CHEMBL4008258) |
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| IC50 | >200000±n/a nM |
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| Citation |  Siegel, D; Hui, HC; Doerffler, E; Clarke, MO; Chun, K; Zhang, L; Neville, S; Carra, E; Lew, W; Ross, B; Wang, Q; Wolfe, L; Jordan, R; Soloveva, V; Knox, J; Perry, J; Perron, M; Stray, KM; Barauskas, O; Feng, JY; Xu, Y; Lee, G; Rheingold, AL; Ray, AS; Bannister, R; Strickley, R; Swaminathan, S; Lee, WA; Bavari, S; Cihlar, T; Lo, MK; Warren, TK; Mackman, RL Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem60:1648-1661 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-directed RNA polymerase, mitochondrial |
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| Name: | DNA-directed RNA polymerase, mitochondrial |
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| Synonyms: | 2.7.7.6 | DNA-directed RNA polymerase, mitochondrial | MtRPOL | POLRMT | RPOM_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138671.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108039 |
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| Residue: | 1230 |
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| Sequence: | MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSASPQEQDQDRRKDWGHV
ELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQPPRKVQMGAKDATPVPCG
RWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCTR
QAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLLAFFKCCLLTDQLP
LAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYA
AALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSL
PPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKP
TLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVV
RMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASD
AEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSS
RLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHS
GAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQL
FQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEAL
YRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDW
LKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCME
VANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVA
AQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDF
PQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQ
PYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCY
RKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILE
ASQLKETLQAVPKPGAFDLEQVKRSTYFFS
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| BDBM50236025 |
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| n/a |
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| Name | BDBM50236025 |
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| Synonyms: | CHEMBL2016761 | US11149049, No. C2 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H16N5O13P3 |
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| Mol. Mass. | 531.2024 |
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| SMILES | Nc1ncnn2c(ccc12)[C@@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N |r| |
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| Structure | 
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