Reaction Details |
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Target | Cytoplasmic tyrosine-protein kinase BMX |
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Ligand | BDBM50236076 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1658703 (CHEMBL4008315) |
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IC50 | 33±n/a nM |
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Citation | Liang, X; Lv, F; Wang, B; Yu, K; Wu, H; Qi, Z; Jiang, Z; Chen, C; Wang, A; Miao, W; Wang, W; Hu, Z; Liu, J; Liu, X; Zhao, Z; Wang, L; Zhang, S; Ye, Z; Wang, C; Ren, T; Wang, Y; Liu, Q; Liu, J Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor. J Med Chem60:1793-1816 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytoplasmic tyrosine-protein kinase BMX |
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Name: | Cytoplasmic tyrosine-protein kinase BMX |
Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
Type: | Tyrosine-protein kinase |
Mol. Mass.: | 78030.42 |
Organism: | Homo sapiens (Human) |
Description: | P51813 |
Residue: | 675 |
Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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BDBM50236076 |
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n/a |
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Name | BDBM50236076 |
Synonyms: | CHEMBL4098823 |
Type | Small organic molecule |
Emp. Form. | C30H36N8O3 |
Mol. Mass. | 556.6586 |
SMILES | CC(C)C[C@H](N)C(=O)Nc1ccc(C)c(c1)N1Cc2cnc(Nc3ccc(C)c(NC(=O)C=C)c3)nc2N(C)C1=O |r| |
Structure |
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