| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM50236242 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1658902 (CHEMBL4008514) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Gomez, L; Massari, ME; Vickers, T; Freestone, G; Vernier, W; Ly, K; Xu, R; McCarrick, M; Marrone, T; Metz, M; Yan, YG; Yoder, ZW; Lemus, R; Broadbent, NJ; Barido, R; Warren, N; Schmelzer, K; Neul, D; Lee, D; Andersen, CB; Sebring, K; Aertgeerts, K; Zhou, X; Tabatabaei, A; Peters, M; Breitenbucher, JG Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders. J Med Chem60:2037-2051 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-dependent 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 105691.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00408 |
|---|
| Residue: | 941 |
|---|
| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
|
|
|
|---|
| BDBM50236242 |
|---|
| n/a |
|---|
| Name | BDBM50236242 |
|---|
| Synonyms: | CHEMBL4093237 | US11186582, Example 516 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21F2N5O2 |
|---|
| Mol. Mass. | 401.4098 |
|---|
| SMILES | COc1ccc(cc1C)C(=O)N1CC(CC(F)(F)C1)c1cc(C)nc2ncnn12 |
|---|
| Structure | 
|
|---|
Search and Browse
