| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase 1, cytoplasmic |
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| Ligand | BDBM50236287 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658998 (CHEMBL4008610) |
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| IC50 | 4100±n/a nM |
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| Citation |  Ng, HL; Ma, X; Chew, EH; Chui, WK Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase. J Med Chem60:1734-1745 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase 1, cytoplasmic |
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| Name: | Thioredoxin reductase 1, cytoplasmic |
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| Synonyms: | NADPH-dependent thioredoxin reductase | TR | TRXR1_RAT | Thioredoxin reductase TR1 | Trxr1 | Txnrd1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54519.34 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_589950 |
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| Residue: | 498 |
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| Sequence: | MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCG
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| BDBM50236287 |
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| n/a |
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| Name | BDBM50236287 |
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| Synonyms: | CHEMBL4071967 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28ClN5O3 |
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| Mol. Mass. | 457.953 |
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| SMILES | Cl.CC1(C)N=C(N)N=C(N)N1OCCCOc1cccc(\C=C\C(=O)c2ccccc2)c1 |t:3,6| |
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| Structure | 
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