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TargetThioredoxin reductase 1, cytoplasmic
LigandBDBM50236323
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1658998 (CHEMBL4008610)
IC50 7500±n/a nM
Citation Ng, HLMa, XChew, EHChui, WK Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase. J Med Chem60:1734-1745 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thioredoxin reductase 1, cytoplasmic
Name:Thioredoxin reductase 1, cytoplasmic
Synonyms:NADPH-dependent thioredoxin reductase | TR | TRXR1_RAT | Thioredoxin reductase TR1 | Trxr1 | Txnrd1
Type:PROTEIN
Mol. Mass.:54519.34
Organism:Rattus norvegicus
Description:ChEMBL_589950
Residue:498
Sequence:
MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50236323
n/a
NameBDBM50236323
Synonyms:CHEMBL4070144
TypeSmall organic molecule
Emp. Form.C25H30ClN5O3
Mol. Mass.483.99
SMILESCl.NC1=NC2(CCCC2)N(OCCCOc2cccc(c2)C(=O)\C=C\c2ccccc2)C(N)=N1 |c:34,t:1|
Structure
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