| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific histone demethylase 2 |
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| Ligand | BDBM50236444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1659184 |
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| IC50 | 12900±n/a nM |
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| Citation |  Vianello, P; Sartori, L; Amigoni, F; Cappa, A; Fagá, G; Fattori, R; Legnaghi, E; Ciossani, G; Mattevi, A; Meroni, G; Moretti, L; Cecatiello, V; Pasqualato, S; Romussi, A; Thaler, F; Trifiró, P; Villa, M; Botrugno, OA; Dessanti, P; Minucci, S; Vultaggio, S; Zagarrí, E; Varasi, M; Mercurio, C Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J Med Chem60:1693-1715 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific histone demethylase 2 |
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| Name: | Lysine-specific histone demethylase 2 |
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| Synonyms: | AOF1 | C6orf193 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B | KDM1B_HUMAN | LSD2 | Lysine-specific histone demethylase 1B | Lysine-specific histone demethylase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92112.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_992590 |
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| Residue: | 822 |
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| Sequence: | MATPRGRTKKKASFDHSPDSLPLRSSGRQAKKKATETTDEDEDGGSEKKYRKCEKAGCTA
TCPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYTTWKKIWTSN
GKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLTPQIAKTYRCGMKPNTAIKPE
TSDHCSLPEDLRVLEVSNHWWYSMLILPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTNRA
AATGNASPGKLEHSKAALSVHVPGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEY
SRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKG
LINTGVLSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGR
VWDDKSFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTID
KRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHL
SNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQC
IDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIE
KIALQFPYRFWDSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVAS
VRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD
IIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
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| BDBM50236444 |
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| n/a |
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| Name | BDBM50236444 |
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| Synonyms: | CHEMBL4090812 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N3O4S |
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| Mol. Mass. | 519.655 |
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| SMILES | CCOCc1cccc(NC(=O)c2cc3sccc3n2C)c1COc1ccc(OC[C@@H]2CCNC2)cc1 |r| |
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| Structure | 
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