| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Ligand | BDBM50236542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1659282 (CHEMBL4008894) |
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| IC50 | 724±n/a nM |
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| Citation |  Zhou, Q; Phoa, AF; Abbassi, RH; Hoque, M; Reekie, TA; Font, JS; Ryan, RM; Stringer, BW; Day, BW; Johns, TG; Munoz, L; Kassiou, M Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma. J Med Chem60:2052-2070 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Synonyms: | DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66690.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1508025 |
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| Residue: | 601 |
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| Sequence: | MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S
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| BDBM50236542 |
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| n/a |
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| Name | BDBM50236542 |
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| Synonyms: | CHEMBL4088888 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H17N3O3S |
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| Mol. Mass. | 379.432 |
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| SMILES | CS(=O)(=O)Nc1ccc(cc1)-c1cnc2[nH]cc(-c3ccc(O)cc3)c2c1 |
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| Structure | 
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