Ki Summary

Reaction Details

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Target

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Ligand

BDBM100152

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1659328

IC50

410±n/a nM

Citation

Zhou, Q; Phoa, AF; Abbassi, RH; Hoque, M; Reekie, TA; Font, JS; Ryan, RM; Stringer, BW; Day, BW; Johns, TG; Munoz, L; Kassiou, M Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma. J Med Chem60:2052-2070 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Name:

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Synonyms:

DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3

Type:

PROTEIN

Mol. Mass.:

65747.26

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1508026

Residue:

588

Sequence:

MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPR
RLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKS
SDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHG
VIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMV
RNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIK
KNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSC
FEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLAC
MMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGS
KDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKR
VVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS

BDBM100152

n/a

Name

BDBM100152

Synonyms:

7-methoxy-1-methyl-9H-beta-carboline;hydrochloride | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | HARMINE | Harmine hydrochloride | MLS002153910 | SMR001233259 | cid_5359389

Type

Small organic molecule

Emp. Form.

C13H12N2O

Mol. Mass.

212.2472

SMILES

COc1ccc2c(c1)[nH]c1c(C)nccc21

Structure