Ki Summary

Reaction Details

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Target

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Ligand

BDBM50236547

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1659284

IC50

198±n/a nM

Citation

Zhou, Q; Phoa, AF; Abbassi, RH; Hoque, M; Reekie, TA; Font, JS; Ryan, RM; Stringer, BW; Day, BW; Johns, TG; Munoz, L; Kassiou, M Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma. J Med Chem60:2052-2070 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Name:

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Synonyms:

DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK

Type:

Enzyme

Mol. Mass.:

69222.24

Organism:

Homo sapiens (Human)

Description:

Q9Y463

Residue:

629

Sequence:

MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS

BDBM50236547

n/a

Name

BDBM50236547

Synonyms:

CHEMBL4075959

Type

Small organic molecule

Emp. Form.

C19H13N3O3

Mol. Mass.

331.3248

SMILES

Oc1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)[N+]([O-])=O

Structure