| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 6 |
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| Ligand | BDBM50236912 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1659751 (CHEMBL4009363) |
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| Ki | 6.0±n/a nM |
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| Citation |  St-Georges, C; Désilets, A; Béliveau, F; Ghinet, M; Dion, SP; Colombo, É; Boudreault, PL; Najmanovich, RJ; Leduc, R; Marsault, É Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem129:110-123 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 6 |
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| Name: | Transmembrane protease serine 6 |
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| Synonyms: | Matriptase-2 | TMPRSS6 | TMPS6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90001.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1442547 |
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| Residue: | 811 |
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| Sequence: | MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
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| BDBM50236912 |
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| n/a |
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| Name | BDBM50236912 |
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| Synonyms: | CHEMBL4093566 |
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| Type | Small organic molecule |
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| Emp. Form. | C39H51N7O5S |
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| Mol. Mass. | 729.931 |
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| SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r,TLB:19:20:23:27.25.26,THB:25:24:21:27.26.28,25:26:23.24.29:21,28:26:23:29.20.21,28:20:23:27.25.26| |
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| Structure | 
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