Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTransmembrane protease serine 6
LigandBDBM50236913
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1659751 (CHEMBL4009363)
Ki 6.0±n/a nM
Citation St-Georges, CDésilets, ABéliveau, FGhinet, MDion, SPColombo, ÉBoudreault, PLNajmanovich, RJLeduc, RMarsault, É Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem129:110-123 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transmembrane protease serine 6
Name:Transmembrane protease serine 6
Synonyms:Matriptase-2 | TMPRSS6 | TMPS6_HUMAN
Type:PROTEIN
Mol. Mass.:90001.12
Organism:Homo sapiens (Human)
Description:ChEMBL_1442547
Residue:811
Sequence:
MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50236913
n/a
NameBDBM50236913
Synonyms:CHEMBL4065964
TypeSmall organic molecule
Emp. Form.C33H45N7O5S
Mol. Mass.651.819
SMILESCC(C)CCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: