| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transmembrane protease serine 6 |
|---|
| Ligand | BDBM50236925 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1659751 (CHEMBL4009363) |
|---|
| Ki | 5.2±n/a nM |
|---|
| Citation |  St-Georges, C; Désilets, A; Béliveau, F; Ghinet, M; Dion, SP; Colombo, É; Boudreault, PL; Najmanovich, RJ; Leduc, R; Marsault, É Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem129:110-123 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transmembrane protease serine 6 |
|---|
| Name: | Transmembrane protease serine 6 |
|---|
| Synonyms: | Matriptase-2 | TMPRSS6 | TMPS6_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 90001.12 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1442547 |
|---|
| Residue: | 811 |
|---|
| Sequence: | MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLL
ALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
MLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELL
STVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDH
LASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVE
VLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYY
SPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAE
RIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDC
PNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCED
RSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRH
ICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYH
EEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNAL
QKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGL
VSWGLGCGRPNYFGVYTRITGVISWIQQVVT
|
|
|
|---|
| BDBM50236925 |
|---|
| n/a |
|---|
| Name | BDBM50236925 |
|---|
| Synonyms: | CHEMBL4084785 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C38H47N7O4S |
|---|
| Mol. Mass. | 697.889 |
|---|
| SMILES | CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
