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TargetProcathepsin L
LigandBDBM50237009
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1661378 (CHEMBL4010990)
Ki 167±n/a nM
Citation Kuhn, BTichư, MWang, LRobinson, SMartin, REKuglstatter, ABenz, JGiroud, MSchirmeister, TAbel, RDiederich, FHert, J Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors. J Med Chem60:2485-2497 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Procathepsin L
Name:Procathepsin L
Synonyms:CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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  Blast E-value cutoff:
BDBM50237009
n/a
NameBDBM50237009
Synonyms:CHEMBL4085357
TypeSmall organic molecule
Emp. Form.C21H16ClFN4O3
Mol. Mass.426.828
SMILESFc1cnc(nc1N(CCOc1ccc(Cl)cc1)Cc1ccc2OCOc2c1)C#N
Structure
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