Reaction Details |
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Target | Procathepsin L |
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Ligand | BDBM50237009 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1661378 (CHEMBL4010990) |
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Ki | 167±n/a nM |
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Citation | Kuhn, B; Tichư, M; Wang, L; Robinson, S; Martin, RE; Kuglstatter, A; Benz, J; Giroud, M; Schirmeister, T; Abel, R; Diederich, F; Hert, J Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors. J Med Chem60:2485-2497 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Procathepsin L |
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Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM50237009 |
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n/a |
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Name | BDBM50237009 |
Synonyms: | CHEMBL4085357 |
Type | Small organic molecule |
Emp. Form. | C21H16ClFN4O3 |
Mol. Mass. | 426.828 |
SMILES | Fc1cnc(nc1N(CCOc1ccc(Cl)cc1)Cc1ccc2OCOc2c1)C#N |
Structure |
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