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Targetm7GpppX diphosphatase
LigandBDBM36530
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1660723 (CHEMBL4010335)
IC50 0.080000±n/a nM
Citation Gopalsamy, ANarayanan, ALiu, SParikh, MDKyne, REFadeyi, OTones, MACherry, JJNabhan, JFLaRosa, GPetersen, DNMenard, CFoley, TLNoell, SRen, YLoria, PMMaglich-Goodwin, JRong, HJones, LH Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem60:3094-3108 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
m7GpppX diphosphatase
Name:m7GpppX diphosphatase
Synonyms:DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:Enzyme
Mol. Mass.:38606.80
Organism:Homo sapiens (Human)
Description:Q96C86
Residue:337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDK
IIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFP
PRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNIL
DKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPL
LRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAE
VIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM36530
n/a
NameBDBM36530
Synonyms:D157493
TypeSmall organic molecule
Emp. Form.C21H23Cl2N5O
Mol. Mass.432.346
SMILESNc1nc(N)c2c(OCC3CCN(Cc4cccc(Cl)c4Cl)CC3)cccc2n1
Structure
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