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TargetDopamine receptor D2L/neurotensin receptor NTS1
LigandBDBM50130293
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1661599
Ki 0.480000±n/a nM
Citation Bonifazi AYano HEllenberger MPMuller LKumar VZou MFCai NSGuerrero AMWoods ASShi LNewman AH Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D J Med Chem 60:2890-2907 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine receptor D2L/neurotensin receptor NTS1
Name:Dopamine receptor D2L/neurotensin receptor NTS1
Synonyms:DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like
Type:Cell-surface receptors
Mol. Mass.:50647.10
Organism:Homo sapiens (Human)
Description:P14416
Residue:443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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  Blast E-value cutoff:
BDBM50130293
n/a
NameBDBM50130293
Synonyms:7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one | ARIPIPRAZOLE | CHEMBL1112 | US10174011, aripiprazole | US9018213, aripprazole | US9156822, Aripiprazole
TypeSmall organic molecule
Emp. Form.C23H27Cl2N3O2
Mol. Mass.448.385
SMILESClc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Structure
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