Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
LigandBDBM50237390
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1660050 (CHEMBL4009662)
Ki 7760±n/a nM
Citation Liu, YXie, ZZhao, DZhu, JMao, FTang, SXu, HLuo, CGeng, MHuang, MLi, J Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors. J Med Chem60:2227-2244 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Name:[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Synonyms:PDHK3 | PDK3 | PDK3_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 3 (PDK3) | Pyruvate dehydrogenase kinase isoform 3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Type:Enzyme
Mol. Mass.:46944.89
Organism:Homo sapiens (Human)
Description:Q15120
Residue:406
Sequence:
MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT
MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN
DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH
PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH
LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL
FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA
LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50237390
n/a
NameBDBM50237390
Synonyms:CHEMBL4099635
TypeSmall organic molecule
Emp. Form.C12H20N2O2S4
Mol. Mass.352.559
SMILESS=C(SSC(=S)N1CCCOCC1)N1CCCOCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: