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TargetSphingosine kinase 2
LigandBDBM50237420
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1660111 (CHEMBL4009723)
IC50 164±n/a nM
Citation Schnute, MEMcReynolds, MDCarroll, JChrencik, JHighkin, MKIyanar, KJerome, GRains, JWSaabye, MScholten, JAYates, MNagiec, MM Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits. J Med Chem60:2562-2572 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine kinase 2
Name:Sphingosine kinase 2
Synonyms:SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2)
Type:Protein
Mol. Mass.:69221.44
Organism:Homo sapiens (Human)
Description:Q9NRA0
Residue:654
Sequence:
MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50237420
n/a
NameBDBM50237420
Synonyms:CHEMBL4090361
TypeSmall organic molecule
Emp. Form.C26H29NO4S
Mol. Mass.451.578
SMILESOC[C@H]1CCCN1Cc1ccc(COc2cccc(CS(=O)(=O)c3ccccc3)c2)cc1 |r|
Structure
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