Reaction Details |
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Target | Sphingosine kinase 2 |
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Ligand | BDBM50237433 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1660111 (CHEMBL4009723) |
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IC50 | 145±n/a nM |
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Citation | Schnute, ME; McReynolds, MD; Carroll, J; Chrencik, J; Highkin, MK; Iyanar, K; Jerome, G; Rains, JW; Saabye, M; Scholten, JA; Yates, M; Nagiec, MM Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits. J Med Chem60:2562-2572 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine kinase 2 |
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Name: | Sphingosine kinase 2 |
Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
Type: | Protein |
Mol. Mass.: | 69221.44 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRA0 |
Residue: | 654 |
Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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BDBM50237433 |
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n/a |
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Name | BDBM50237433 |
Synonyms: | CHEMBL4063506 |
Type | Small organic molecule |
Emp. Form. | C26H28N2O3 |
Mol. Mass. | 416.5121 |
SMILES | OC[C@H]1CCCN1Cc1ccc(COc2cccc(NC(=O)c3ccccc3)c2)cc1 |r| |
Structure |
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