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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 9 subunit alpha | ||
| Ligand | BDBM50237519 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1660138 (CHEMBL4009750) | ||
| IC50 | 398±n/a nM | ||
| Citation |  Wu, YJ; Guernon, J; Shi, J; Ditta, J; Robbins, KJ; Rajamani, R; Easton, A; Newton, A; Bourin, C; Mosure, K; Soars, MG; Knox, RJ; Matchett, M; Pieschl, RL; Post-Munson, DJ; Wang, S; Herrington, J; Graef, J; Newberry, K; Bristow, LJ; Meanwell, NA; Olson, R; Thompson, LA; Dzierba, C Development of New Benzenesulfonamides As Potent and Selective Na J Med Chem60:2513-2525 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 9 subunit alpha | |||
| Name: | Sodium channel protein type 9 subunit alpha | ||
| Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
| Type: | Protein | ||
| Mol. Mass.: | 226375.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15858 | ||
| Residue: | 1988 | ||
| Sequence: |
| ||
| BDBM50237519 | |||
| n/a | |||
| Name | BDBM50237519 | ||
| Synonyms: | CHEMBL4097237 | US10836758, Example 21 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H20ClFN4O2S2 | ||
| Mol. Mass. | 418.937 | ||
| SMILES | N[C@H]1CC[C@H](CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)CC1 |r,wU:1.0,wD:4.4,(46.21,-58.36,;47.55,-57.58,;47.55,-56.04,;48.89,-55.27,;50.21,-56.04,;51.54,-55.27,;51.52,-53.72,;52.86,-52.92,;52.86,-51.39,;54.19,-50.61,;54.19,-49.08,;55.53,-51.38,;55.53,-52.93,;54.19,-53.69,;54.19,-55.23,;56.86,-50.6,;56.09,-49.26,;57.63,-49.26,;58.21,-51.37,;59.53,-50.59,;59.53,-49.05,;60.99,-48.58,;61.89,-49.81,;61,-51.06,;50.21,-57.58,;48.88,-58.35,)| | ||
| Structure | 
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