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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel alpha subunit | ||
| Ligand | BDBM50237499 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1660138 | ||
| IC50 | 16±n/a nM | ||
| Citation |  Wu YJ; Guernon J; Shi J; Ditta J; Robbins KJ; Rajamani R; Easton A; Newton A; Bourin C; Mosure K; Soars MG; Knox RJ; Matchett M; Pieschl RL; Post-Munson DJ; Wang S; Herrington J; Graef J; Newberry K; Bristow LJ; Meanwell NA; Olson R; Thompson LA; Dzierba C Development of New Benzenesulfonamides As Potent and Selective Na J Med Chem 60:2513-2525 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel alpha subunit | |||
| Name: | Sodium channel alpha subunit | ||
| Synonyms: | Neuroendocrine sodium channel | Peripheral sodium channel 1 | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
| Type: | Protein | ||
| Mol. Mass.: | 226375.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15858 | ||
| Residue: | 1988 | ||
| Sequence: |
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| BDBM50237499 | |||
| n/a | |||
| Name | BDBM50237499 | ||
| Synonyms: | CHEMBL4076627 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H19ClFN5O2S2 | ||
| Mol. Mass. | 419.925 | ||
| SMILES | N[C@H]1CC[C@@H](CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2ncns2)CC1 |r,wU:4.4,1.0,(19.01,-58.71,;20.34,-57.93,;20.34,-56.39,;21.68,-55.62,;23.01,-56.39,;24.33,-55.62,;24.31,-54.07,;25.66,-53.28,;25.66,-51.74,;26.98,-50.96,;26.98,-49.43,;28.32,-51.73,;28.32,-53.28,;26.99,-54.05,;26.98,-55.58,;29.66,-50.95,;28.88,-49.61,;30.43,-49.61,;31.01,-51.72,;32.33,-50.94,;32.32,-49.41,;33.78,-48.94,;34.69,-50.16,;33.79,-51.42,;23.01,-57.93,;21.68,-58.7,)| | ||
| Structure | 
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