Reaction Details | |||
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Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM50237517 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1660141 (CHEMBL4009753) | ||
IC50 | 12±n/a nM | ||
Citation | Wu, YJ; Guernon, J; Shi, J; Ditta, J; Robbins, KJ; Rajamani, R; Easton, A; Newton, A; Bourin, C; Mosure, K; Soars, MG; Knox, RJ; Matchett, M; Pieschl, RL; Post-Munson, DJ; Wang, S; Herrington, J; Graef, J; Newberry, K; Bristow, LJ; Meanwell, NA; Olson, R; Thompson, LA; Dzierba, C Development of New Benzenesulfonamides As Potent and Selective Na J Med Chem60:2513-2525 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | PN1 | Peripheral sodium channel 1 | SCN9A_RAT | Scn9a | Sodium channel protein type 9 subunit alpha | Sodium channel protein type IX alpha subunit | Sodium channel protein type IX subunit alpha | Voltage-gated sodium channel | Voltage-gated sodium channel subunit alpha Nav1.7 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 226035.47 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1516887 | ||
Residue: | 1984 | ||
Sequence: |
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BDBM50237517 | |||
n/a | |||
Name | BDBM50237517 | ||
Synonyms: | CHEMBL4078268 | US10836758, Example 20 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H20ClFN4O2S2 | ||
Mol. Mass. | 418.937 | ||
SMILES | N[C@H]1CC[C@@H](CNc2cc(F)c(cc2Cl)S(=O)(=O)Nc2nccs2)CC1 |r,wU:4.4,1.0,(32.42,-58.42,;33.76,-57.64,;33.76,-56.1,;35.1,-55.33,;36.43,-56.1,;37.75,-55.33,;37.73,-53.78,;39.08,-52.99,;39.08,-51.45,;40.4,-50.67,;40.4,-49.14,;41.74,-51.44,;41.74,-52.99,;40.41,-53.75,;40.4,-55.29,;43.08,-50.66,;42.3,-49.32,;43.85,-49.32,;44.43,-51.43,;45.75,-50.65,;45.74,-49.12,;47.2,-48.65,;48.11,-49.87,;47.21,-51.13,;36.43,-57.64,;35.1,-58.41,)| | ||
Structure |