Reaction Details | |||
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Target | Sodium channel protein type 5 subunit alpha | ||
Ligand | BDBM50237511 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1660139 (CHEMBL4009751) | ||
IC50 | >30000±n/a nM | ||
Citation | Wu, YJ; Guernon, J; Shi, J; Ditta, J; Robbins, KJ; Rajamani, R; Easton, A; Newton, A; Bourin, C; Mosure, K; Soars, MG; Knox, RJ; Matchett, M; Pieschl, RL; Post-Munson, DJ; Wang, S; Herrington, J; Graef, J; Newberry, K; Bristow, LJ; Meanwell, NA; Olson, R; Thompson, LA; Dzierba, C Development of New Benzenesulfonamides As Potent and Selective Na J Med Chem60:2513-2525 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 5 subunit alpha | |||
Name: | Sodium channel protein type 5 subunit alpha | ||
Synonyms: | HH1 | SCN5A | SCN5A_HUMAN | Sodium channel alpha subunit | Sodium channel protein type 5 subunit alpha/beta-1/beta-2 | Sodium channel protein type V alpha subunit | Voltage-gated sodium channel subunit alpha Nav1.5 | ||
Type: | Enzyme | ||
Mol. Mass.: | 226908.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14524 | ||
Residue: | 2016 | ||
Sequence: |
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BDBM50237511 | |||
n/a | |||
Name | BDBM50237511 | ||
Synonyms: | CHEMBL4072007 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H26F2N4O3S2 | ||
Mol. Mass. | 508.604 | ||
SMILES | CN[C@H]1CC[C@@](CCOc2cc(F)c(cc2F)S(=O)(=O)Nc2ncns2)(CC1)c1ccccc1 |r,wU:5.5,2.1,(27.81,-33.45,;26.5,-32.64,;26.55,-31.1,;25.25,-30.29,;25.3,-28.76,;26.65,-28.04,;27.42,-26.71,;28.96,-26.72,;29.72,-28.06,;31.26,-28.06,;32.03,-26.74,;33.56,-26.74,;34.33,-25.41,;34.33,-28.09,;33.55,-29.41,;32.02,-29.41,;31.24,-30.73,;35.87,-28.09,;36.28,-26.6,;37.37,-27.7,;36.63,-29.43,;38.17,-29.43,;39.08,-28.19,;40.54,-28.67,;40.54,-30.21,;39.07,-30.68,;27.96,-28.83,;27.91,-30.38,;25.55,-26.94,;25.96,-25.43,;24.86,-24.33,;23.35,-24.73,;22.95,-26.25,;24.05,-27.34,)| | ||
Structure |