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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50237735
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1661768 (CHEMBL4011380)
Ki 2.4±n/a nM
Citation Aguilar, A; Lu, J; Liu, L; Du, D; Bernard, D; McEachern, D; Przybranowski, S; Li, X; Luo, R; Wen, B; Sun, D; Wang, H; Wen, J; Wang, G; Zhai, Y; Guo, M; Yang, D; Wang, S Discovery of 4-((3'R,4'S,5'R)-6¿-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2¿-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3¿-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Deve J Med Chem60:2819-2839 (2017) [PubMed]  Article
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E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM50237735
n/a
NameBDBM50237735
Synonyms:CHEMBL4100233
TypeSmall organic molecule
Emp. Form.C29H32Cl2FN3O3
Mol. Mass.560.487
SMILESCC1(C)CC2(C1)N[C@H]([C@H](c1cccc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc12)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:17.20,8.9,31.35,wD:7.32,34.39,(50.67,-37.89,;49.19,-38.3,;50.28,-39.38,;47.86,-39.06,;47.1,-37.73,;48.43,-36.97,;47.17,-36.2,;45.73,-35.65,;44.68,-36.88,;43.34,-35.36,;43.04,-33.84,;41.58,-33.34,;40.42,-34.35,;40.72,-35.87,;39.55,-36.88,;42.17,-36.37,;43.86,-37.35,;45.61,-38.14,;46.53,-39.39,;47.93,-40.55,;45.62,-40.65,;44.14,-40.18,;42.8,-40.95,;41.47,-40.18,;40.14,-40.95,;41.47,-38.64,;42.8,-37.87,;44.14,-38.63,;45.33,-34.17,;43.84,-33.77,;46.41,-33.07,;47.9,-33.47,;48.97,-32.37,;50.47,-32.77,;50.87,-34.26,;52.35,-34.65,;49.78,-35.34,;48.3,-34.95,)|
Structure
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