| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
|---|
| Ligand | BDBM50237672 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1662268 (CHEMBL4011949) |
|---|
| IC50 | 5.3±n/a nM |
|---|
| Citation |  Irie, T; Asami, T; Sawa, A; Uno, Y; Hanada, M; Taniyama, C; Funakoshi, Y; Masai, H; Sawa, M Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem130:406-418 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity protein kinase CLK2 |
|---|
| Name: | Dual specificity protein kinase CLK2 |
|---|
| Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 60128.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49760 |
|---|
| Residue: | 499 |
|---|
| Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
|
|
|
|---|
| BDBM50237672 |
|---|
| n/a |
|---|
| Name | BDBM50237672 |
|---|
| Synonyms: | CHEMBL4089159 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H14ClN3O4 |
|---|
| Mol. Mass. | 395.796 |
|---|
| SMILES | COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
