| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50237707 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1662406 |
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| IC50 | 9.0±n/a nM |
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| Citation |  O'Brien-Brown, J; Jackson, A; Reekie, TA; Barron, ML; Werry, EL; Schiavini, P; McDonnell, M; Munoz, L; Wilkinson, S; Noll, B; Wang, S; Kassiou, M Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X Eur J Med Chem130:433-439 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68403.50 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q64663 |
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| Residue: | 595 |
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| Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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| BDBM50237707 |
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| n/a |
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| Name | BDBM50237707 |
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| Synonyms: | A-804598 | CHEMBL1628690 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N5 |
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| Mol. Mass. | 315.3718 |
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| SMILES | C[C@H](N\C(Nc1cccc2ncccc12)=N\C#N)c1ccccc1 |r| |
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| Structure | 
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