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TargetCytochrome P450 3A4
LigandBDBM342909
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1662545 (CHEMBL4012226)
IC50>27000±n/a nM
Citation Weiss, MMDineen, TAMarx, IEAltmann, SBoezio, ABregman, HChu-Moyer, MDiMauro, EFFeric Bojic, EFoti, RSGao, HGraceffa, RGunaydin, HGuzman-Perez, AHuang, HHuang, LJarosh, MKornecook, TKreiman, CRLigutti, JLa, DSLin, MJLiu, DMoyer, BDNguyen, HNPeterson, EARose, PETaborn, KYoungblood, BDYu, VFremeau, RT Sulfonamides as Selective Na J Med Chem60:5969-5989 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 3A4
Name:Cytochrome P450 3A4
Synonyms:Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase
Type:Enzyme
Mol. Mass.:57349.57
Organism:Homo sapiens (Human)
Description:n/a
Residue:503
Sequence:
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM342909
n/a
NameBDBM342909
Synonyms:1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-N-3-pyridazinyl-6-isoquinolinesulfonamide | US9776995, Example 120
TypeSmall organic molecule
Emp. Form.C26H18ClFN4O3S
Mol. Mass.520.963
SMILESCOc1cc(c(Cl)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1cccnn1)-c1cccc(F)c1
Structure
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