Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM50237990 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1662647 (CHEMBL4012328) | ||
IC50 | 160±n/a nM | ||
Citation | Graceffa, RF; Boezio, AA; Able, J; Altmann, S; Berry, LM; Boezio, C; Butler, JR; Chu-Moyer, M; Cooke, M; DiMauro, EF; Dineen, TA; Feric Bojic, E; Foti, RS; Fremeau, RT; Guzman-Perez, A; Gao, H; Gunaydin, H; Huang, H; Huang, L; Ilch, C; Jarosh, M; Kornecook, T; Kreiman, CR; La, DS; Ligutti, J; Milgram, BC; Lin, MJ; Marx, IE; Nguyen, HN; Peterson, EA; Rescourio, G; Roberts, J; Schenkel, L; Shimanovich, R; Sparling, BA; Stellwagen, J; Taborn, K; Vaida, KR; Wang, J; Yeoman, J; Yu, V; Zhu, D; Moyer, BD; Weiss, MM Sulfonamides as Selective Na J Med Chem60:5990-6017 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
| ||
BDBM50237990 | |||
n/a | |||
Name | BDBM50237990 | ||
Synonyms: | CHEMBL4069051 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H16F2N4O5S | ||
Mol. Mass. | 534.491 | ||
SMILES | COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1ccc(C#N)c(F)c1 |(11.87,-30.75,;10.54,-31.53,;10.55,-33.07,;11.89,-33.83,;11.9,-35.38,;10.57,-36.15,;10.57,-37.7,;9.23,-35.39,;9.23,-33.85,;7.89,-33.09,;7.88,-31.54,;9.21,-30.77,;9.2,-29.24,;7.87,-28.47,;6.55,-29.24,;6.55,-30.77,;5.22,-31.54,;5.22,-33.09,;6.55,-33.86,;6.55,-35.4,;7.85,-26.93,;6.36,-26.52,;7.46,-25.43,;9.19,-26.15,;9.18,-24.61,;7.93,-23.72,;8.4,-22.25,;9.94,-22.24,;10.42,-23.7,;13.24,-36.14,;13.24,-37.69,;14.58,-38.45,;15.91,-37.67,;17.25,-38.43,;18.59,-39.19,;15.9,-36.12,;17.23,-35.34,;14.56,-35.37,)| | ||
Structure |