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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 9 subunit alpha | ||
| Ligand | BDBM342945 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1662647 (CHEMBL4012328) | ||
| IC50 | 59.0±n/a nM | ||
| Citation |  Graceffa, RF; Boezio, AA; Able, J; Altmann, S; Berry, LM; Boezio, C; Butler, JR; Chu-Moyer, M; Cooke, M; DiMauro, EF; Dineen, TA; Feric Bojic, E; Foti, RS; Fremeau, RT; Guzman-Perez, A; Gao, H; Gunaydin, H; Huang, H; Huang, L; Ilch, C; Jarosh, M; Kornecook, T; Kreiman, CR; La, DS; Ligutti, J; Milgram, BC; Lin, MJ; Marx, IE; Nguyen, HN; Peterson, EA; Rescourio, G; Roberts, J; Schenkel, L; Shimanovich, R; Sparling, BA; Stellwagen, J; Taborn, K; Vaida, KR; Wang, J; Yeoman, J; Yu, V; Zhu, D; Moyer, BD; Weiss, MM Sulfonamides as Selective Na J Med Chem60:5990-6017 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 9 subunit alpha | |||
| Name: | Sodium channel protein type 9 subunit alpha | ||
| Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
| Type: | Protein | ||
| Mol. Mass.: | 226375.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15858 | ||
| Residue: | 1988 | ||
| Sequence: |
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| BDBM342945 | |||
| n/a | |||
| Name | BDBM342945 | ||
| Synonyms: | 1-(2,3''-difluoro-5-methoxy-4-biphenylyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6-quinolinesulfonamide | US9776995, Example 298 | US9776995, Example 299 | US9776995, Example 42 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H17F2N3O5S | ||
| Mol. Mass. | 509.481 | ||
| SMILES | COc1cc(c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1 |(-.11,-.1,;1.22,-.87,;2.55,-.1,;2.55,1.44,;3.89,2.21,;5.22,1.44,;6.55,2.21,;5.22,-.1,;3.89,-.87,;3.89,-2.41,;2.55,-3.18,;1.22,-2.41,;-.11,-3.18,;-.11,-4.72,;1.22,-5.49,;2.55,-4.72,;3.89,-5.49,;5.22,-4.72,;5.22,-3.18,;6.55,-2.41,;-1.45,-5.49,;-2.22,-4.16,;-.68,-6.83,;-2.78,-6.26,;-4.12,-5.49,;-5.52,-6.12,;-6.55,-4.98,;-5.78,-3.64,;-4.28,-3.96,;3.89,3.75,;5.22,4.52,;5.22,6.06,;3.89,6.83,;2.55,6.06,;1.22,6.83,;2.55,4.52,)| | ||
| Structure | 
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