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TargetGeranylgeranyl pyrophosphate synthase
LigandBDBM50151859
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1662613 (CHEMBL4012294)
IC50 170±n/a nM
Citation Wills, VSMetzger, JIAllen, CVarney, MLWiemer, DFHolstein, SA Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase. Bioorg Med Chem25:2437-2444 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Geranylgeranyl pyrophosphate synthase
Name:Geranylgeranyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:Homooctamer; transferase
Mol. Mass.:34867.94
Organism:Homo sapiens (Human)
Description:Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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  Blast E-value cutoff:
BDBM50151859
n/a
NameBDBM50151859
Synonyms:CHEMBL3775876
TypeSmall organic molecule
Emp. Form.C15H23N3Na4O6P2
Mol. Mass.495.2662
SMILES[Na+].[Na+].[Na+].[Na+].[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-n1cc(-[#6]-[#6](P([#8-])([#8-])=O)P([#8-])([#8-])=O)nn1
Structure
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