Reaction Details |
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Target | Kynurenine 3-monooxygenase |
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Ligand | BDBM50238004 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1662711 (CHEMBL4012392) |
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IC50 | 40±n/a nM |
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Citation | Liddle, J; Beaufils, B; Binnie, M; Bouillot, A; Denis, AA; Hann, MM; Haslam, CP; Holmes, DS; Hutchinson, JP; Kranz, M; McBride, A; Mirguet, O; Mole, DJ; Mowat, CG; Pal, S; Rowland, P; Trottet, L; Uings, IJ; Walker, AL; Webster, SP The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett27:2023-2028 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine 3-monooxygenase |
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Name: | Kynurenine 3-monooxygenase |
Synonyms: | KMO | KMO_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 55831.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1487479 |
Residue: | 486 |
Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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BDBM50238004 |
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n/a |
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Name | BDBM50238004 |
Synonyms: | CHEMBL4073276 |
Type | Small organic molecule |
Emp. Form. | C10H9BrN2O2 |
Mol. Mass. | 269.095 |
SMILES | OC(=O)CCn1ncc2ccc(Br)cc12 |
Structure |
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