| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine 3-monooxygenase |
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| Ligand | BDBM50083950 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1662733 (CHEMBL4012414) |
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| IC50 | 900±n/a nM |
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| Citation |  Liddle, J; Beaufils, B; Binnie, M; Bouillot, A; Denis, AA; Hann, MM; Haslam, CP; Holmes, DS; Hutchinson, JP; Kranz, M; McBride, A; Mirguet, O; Mole, DJ; Mowat, CG; Pal, S; Rowland, P; Trottet, L; Uings, IJ; Walker, AL; Webster, SP The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis. Bioorg Med Chem Lett27:2023-2028 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine 3-monooxygenase |
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| Name: | Kynurenine 3-monooxygenase |
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| Synonyms: | KMO_RAT | Kmo |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54371.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1487468 |
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| Residue: | 478 |
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| Sequence: | MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSY
RGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLT
AVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKK
PRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMS
FEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCV
LMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLS
MYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKK
VINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
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| BDBM50083950 |
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| n/a |
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| Name | BDBM50083950 |
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| Synonyms: | (S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid[(S)-(+)-m-nicotinylbenzoylalanine] | (S)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid | CHEMBL22740 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H10N2O5 |
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| Mol. Mass. | 238.1968 |
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| SMILES | N[C@@H](CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O |
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| Structure | 
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